ABOUT BOOK

Purpose – The objective of the present study was to determine the effect of monosodium glutamate (MSG) administration to pyramidal cells necrosis on the cerebral cortex of Wistar male rats (Rattus norvegicus).Design/Methodology/Approach – This research was a laboratory quasi-experiment study with post-test control group design on 24 male Wistar rats (Rattus norvegicus) aged 8-10 weeks, weighted 200 ± 10 gr, divided into 4 groups (GI or control group, GII treated with MSG dose 6 mg/grbb/day, GIII 12 mg/grbb/day, and GIV 24 mg/grbb/day) for 21 days consecutively. Pyramidal cells observed in 10 field of view. The Kruskal-Wallis test and Mann Whitney tests were used to analyze the data.Findings – There were significant differences between pyramidal cells necrosis numbers between control and the treatment groups. MSG doses 6, 12, and 24 mg/grbb/day developed the pyramidal cells necrosis in the cerebral cortex (p < 0,005).